Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy ...

New neuroscience research identifies Glutamine Synthetase as the key enzyme driving postnatal brain maturation and neuronal connectivity via the mTOR pathway.

Major depressive disorder (MDD) is a complex and debilitating metal illness. Given its complex and widespread nature, MDD has been a subject of intense medical research. Previous studies have found ...

Malformations of cortical development are commonly associated with epilepsy and intellectual disabilities. Polymicrogyria is one of the most frequent cortical malformations but remains largely ...

The cerebral cortex, the brain's outermost region responsible for higher cognitive functions, depends on a highly ordered, layered structure. Its proper development requires newly generated neurons to ...

The human brain develops through an intricate balance of cellular growth, connectivity, and metabolism. A new study reveals ...

In appearance, the human brain’s outermost layer, called the cortex, is a maze of tissue folds. The peaks or raised surfaces of these folds, called gyri, play an important role in the proper ...

The brain is known to develop gradually throughout the human lifespan, following a hierarchical pattern. First, it adapts to support basic functions, such as movement and sensory perception, then it ...

A Japanese research team has successfully reproduced the human neural circuit in vitro using multi-region miniature organs known as assembloids, which are derived from induced pluripotent stem (iPS) ...