Chromatin assembly in vivo occurs during DNA replication in cycling cells and in a replication-independent fashion throughout the cell cycle. Histone chaperones, such as CAF1, RCAF/ASF1, NAP1 and HIR ...
An essential aspect of building a mammalian cell is packing 1.7 metres of DNA into a 5-micrometre nucleus in a form that allows it to be replicated and transcribed in stable, tissue-specific patterns.
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