Nature

Demystifying the D-loop during DNA recombination

Upasana Roy is in the Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York 10032, USA. Eric C. Greene is in the Department of Biochemistry ...
Nature

Strands of evidence about cancer evolution

Trevor A. Graham is at the Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. Sarah E. McClelland is at the Centre for ...
GEN

DNA/DNA Heteroduplex Construct Suppresses Gene Expression

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...
PBS

Part III: Preparing DNA for Detection

We now have billions of identical copies of a stretch of DNA 2,000 to 4,000 base pairs long. From these we need to create copies with special bases that our machines will be able to read. Instead of ...
The Scientist

With Two RNA Guides, Editing Technique Writes Long DNA Insertions

Researchers in China have developed a new method that allows them to insert long stretches of DNA into a genome. The process, named GRAND editing, is one of a handful of new systems aimed at using two ...