Empagliflozin reduced proinflammatory cytokines and oxidative stress markers in INOCA patients with CMD, improving vascular health. Treatment led to favorable shifts in endothelial extracellular ...

A polygenic risk score (PRS) based on genes associated with endothelial cell function identifies patients at a higher risk of coronary artery disease, according to a new study. The risk score, which ...

Sepsis, a life-threatening systemic inflammatory response triggered by infection, has long challenged clinicians with its persistently high mortality (up to 40-50% in septic shock). At the heart of ...

A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient's blood vessels. Researchers from The University of Queensland and the Queensland Children's ...

With a new $11.3 million Program Project grant from the National Institutes of Health, experts from the Vascular Biology Center at the Medical College of Georgia at Augusta University are working to ...

Sepsis is a life-threatening condition that often leads to ARDS, characterized by widespread inflammation and vascular injury. This study identifies lactate-driven lysine lactylation (Kla) as a ...

For Covid-19 patients with serious lung disease, targeting endothelial cells - cells that comprise the blood vessel wall which regulate oxygen exchange between airways and the bloodstream - may be a ...

The glycocalyx emerges as an active endothelial system whose structure, metabolism, and shear-dependent regulation integrate mechanical forces with vascular signaling. Disruption of this system ...