This study illustrates how persistent mRNA rG4 structures induce ribosome pausing and collisions, leading to proteostasis collapse in senescent cells. The RNA helicase DHX9 acts as a key regulator, ...

Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these ...

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis ...

Researchers from Aarhus University and the Italian Institute of Technology have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

DNA G-quadruplexes (G4s) are a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Although DNA G4s are thought to be involved in various biological processes, in many ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. Present in both DNA and RNA sequences, a G-quadruplex (GQ) is a structure of four guanine bases ...

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease and Stephen Hawking’s disease, is a neurodegenerative disease that results in the gradual loss of control over the muscles ...