Discover how CRISPR genome editing is revolutionizing medicine. Learn the science of Cas9, current clinical trials, and the ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired his specific genetic mutation. The treatment was ...

The pegRNA binds to a matching sequence on the target DNA strand. The Cas9 nickase cuts the unbound complementary strand, creating a flap. The dangling DNA flap binds to a matching sequence on the ...

The trajectory of base editing has been remarkable, progressing from the laboratory to patient care, treating debilitating or ...

A schematic showing the cytosine base editing intermediate and the various outcomes that can occur when the UNG protein is active. You may have seen it in the news recently: a baby in Pennsylvania ...