One of the first intracellular kinases to be explicated as a protooncogene was c-Src, an upstream mediator of both the PI 3-K and MAPK pathways. The amplified c-Src activity has been implicated in ...

Insulin binding to Golgi and plasmalemma fractions from the liver of obese (ob/ob and db/db) and lean control mice was studied. The specificity of binding in Golgi fractions (Golgi vesicles and Golgi ...

Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously ...

The LAT Signalosome The models summarized in the Antigen Discrimination and Intracellular Receptor Phopshorylation sections describe T-cell activation up to the point of ZAP-70 binding to the ...

Announcing a new article publication for Zoonoses journal. Researchers from University of Texas Medical Branch, Galveston, TX, USA review pattern recognition receptors in innate immunity to obligate ...