High-performance liquid chromatography (HPLC) or ultra-high-performance liquid chromatography (UHPLC) serves as the front end of the analysis, reducing sample complexity before mass detection.
The success of any large-scale proteomics study is fundamentally determined at the sample preparation stage, which serves as the critical bridge between the biological system and the analytical ...
Stable isotope-labeled internal standards are widely used in laboratory-developed clinical mass spectrometry tests. An equal amount of these internal standards is added to all samples in a batch, ...
Synthetic oligonucleotides have been used as critical research reagents in the biotechnology industry since its beginning in the 1970s. Their increasing use first led to the formation of many core ...
Figure 1. A schematic representation of a lipid nanoparticle encapsulating mRNA. As this new form of biotechnology makes a leap of progress, so too do the analytical approaches supporting its ...
The quality of data derived from MS can be enhanced by imposing a parameter called selected ion monitoring (SIM), which is highly sensitive and allows quantitative analysis that circumvents effects of ...
Biomarkers play an important role in drug development and help in the identification of disease-causing proteins found in blood, urine, body fluids, and tissue samples. The combination of liquid ...
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