Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...
Mesothelin-targeted CAR-NKT cells leveraged three recognition mechanisms, potentially limiting antigen escape and immunoediting compared with single-pathway CAR-T constructs. Complete tumor ...
The introduction of highly effective direct-acting antivirals has transformed the HCV treatment landscape, enabling cure ...
The power of CRISPR became definitively clear when the first CRISPR-based gene therapy, Casgevy (exa-cel), won regulatory approvals for the treatment of sickle cell disease. But CRISPR’s applications ...
Developing effective cardiovascular therapies requires robust, translational preclinical data that can reliably predict ...
The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical ...
PRI-101 inhibited aggregation of α-synuclein and actively disassembled fibrils across in vitro and in vivo models relevant to Parkinson’s disease ...
D models coupled with live-cell imaging can enhance the overall reliability of preclinical renal safety evaluations.
Tonix Pharmaceuticals presented promising data on TNX-1700 for gastric and colorectal cancers, enhancing anti-PD1 therapy effectiveness in preclinical models. Tonix Pharmaceuticals has announced ...
Zymeworks presents six posters at AACR highlighting advancements in antibody-drug conjugates and T cell engagers, including ZW209's promise in lung cancer. Zymeworks Inc. announced the presentation of ...
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