CRISPR-Cas9 gene editing relies on a guide RNA that binds to a desired DNA sequence and a Cas9 enzyme that cuts both strands of DNA at that site, creating a double-strand break. Scientists edit the ...

Less than 60 minutes after his latest report was published online, Luigi Naldini, MD, PhD, called me to discuss his article, “Genotoxic effects of base and prime editing in human hematopoietic stem ...

The gene-editing method CRISPR has transformed biology, giving scientists the ability to modify genes to treat or prevent genetic diseases by correcting dangerous mutations and to create a host of new ...